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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer’s Disease Mouse Model
doi: 10.3390/ijms18112260
Figure Lengend Snippet: Modulation of APP molecular interaction network in the OB of aged Tg2576 mice. Visual representation of the relationships between differentially expressed genes/proteins and APP functional interactors (blue lines) are shown in both potentially deregulated networks in Tg2576 OBs ( A and B ). Continuous lines represent direct interactions, while discontinuous lines correspond to indirect functional interactions. Up-regulated molecules are shown in red, down-regulated molecules in green, and proteins proposed by the software in white. The complete legend of this type of interactomes may be found at http://ingenuity.force.com/ipa/articles/Feature_Description/Legend (accessed on 10 October 2017).
Article Snippet: For that, differential proteomic and transcriptomic datasets were merged and functionally analyzed across specific biological functions using the
Techniques: Functional Assay, Software
Journal: International Journal of Molecular Sciences
Article Title: Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer’s Disease Mouse Model
doi: 10.3390/ijms18112260
Figure Lengend Snippet: Modulation of CREB1 molecular interactome in the OB of aged Tg2576 mice. Visual representation of the relationships between differential expressed genes/proteins and CREB1 functional interactors (blue lines) are shown in the deregulated network in Tg2576 OBs ( A ); Continuous lines represent direct interactions, while discontinuous lines correspond to indirect functional interactions. Up-regulated molecules are shown in red, down-regulated molecules in green, and molecules proposed by the software in white. The complete legend of this type of interactomes may be found at http://ingenuity.force.com/ipa/articles/Feature_Description/Legend (accessed on 17 October 2017). CREB1 protein levels were down-regulated in the OB of aged Tg2576 mice. * p < 0.05 vs. WT group ( B ). Equal loading control and quantitation values have been included in . a.u., arbitrary units.
Article Snippet: For that, differential proteomic and transcriptomic datasets were merged and functionally analyzed across specific biological functions using the
Techniques: Functional Assay, Software, Control, Quantitation Assay